Changes of reduced glutathione and glutathione S-transferase levels in colorectal cancer patients undergoing treatment
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چکیده
منابع مشابه
Serum Levels of Zinc, Copper, Selenium and Glutathione Peroxidase in Different Groups of Colorectal Cancer Patients
Background: Colorectal cancer (CRC) is considered the fourth type of cancer that causes death in the world. Changes in levels of Zinc (Zn), Copper (Cu), and Selenium (Se) as well as low glutathione peroxidase (GPx) activity can lead to CRC and this study was aimed to evaluate their possible use as diagnostic markers. Methods: CRC patients (n=90) were divided into three groups; newly diagnosed,...
متن کاملIsothiocyanate exposure, glutathione S-transferase polymorphisms, and colorectal cancer risk.
BACKGROUND Isothiocyanates, compounds found primarily in cruciferous vegetables, have been shown in laboratory studies to possess anticarcinogenic activity. Glutathione S-transferases (GSTs) are involved in the metabolism and elimination of isothiocyanates; thus, genetic variations in these enzymes may affect in vivo bioavailability and the activity of isothiocyanates. OBJECTIVE The objective...
متن کاملC. Y. Kadam et al EVALUATION OF SERUM LEVELS OF REDUCED GLUTATHIONE, GLUTATHIONE-S- TRANSFERASE AND NITRIC OXIDE IN BREAST CANCER PATIENTS UNDERGOING ADJUVANT CHEMOTHERAPY
Background: Alteration in oxidative and nitrosative stress as well as antioxidant status is known to occur in carcinogenesis and during treatment of cancer with chemotherapeutic drugs. Objective: The objective of this study was to evaluate the serum levels of reduced glutathione (GSH) glutathione-stransferase (GST) and nitric oxide (NO • ) in post-operative stage II breast cancer patients under...
متن کاملGlutathione S-transferase polymorphisms and colorectal cancer: a HuGE review.
The genes glutathione S-transferase M1 (GSTM1) (chromosome 1p13.3) and glutathione S-transferase T1 (GSTT1) (22q11.2) code for cytosolic enzymes glutathione S-transferase (GST)-mu and GST-theta, respectively, which are involved in phase 2 metabolism. Both genes may be deleted. There is geographic and ethnic variation in genotype frequencies for both genes. In developed countries, colorectal can...
متن کاملGlutathione S-transferase activity and glutathione S-transferase mu expression in subjects with risk for colorectal cancer.
The glutathione S-transferases (alpha, mu, and pi), a family of Phase II detoxication enzymes, play a critical role in protecting the colon mucosa by catalyzing the conjugation of dietary carcinogens with glutathione. We investigated the efficacy of using the glutathione S-transferase (GST) activity of blood lymphocytes and GST-mu expression as biomarkers of risk for colorectal cancer. GST acti...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2017
ISSN: 0923-7534
DOI: 10.1093/annonc/mdx261.276